I've noticed a large degration of signal between Iphone 5 and /or IOS6.    With my Iphone 4 I consistently was able to access mail and internet from my office.  Not a strong enough signal to make long phone calls without dropping, but never an issue getting mail.   

since getting the Iphone 5 I'm constently getting  no service, unable to connect to server, unable to access itunes, etc.   I've never had this issue with the Iphone 4 / IOS5. 

anyone else notice a loss of signal with the new phone/IOS?   I tried taking the case off, same signal issues.